ActinMouse models of asthma

Features:

  • Ovalbumin, house dust mite exposure or mixed allergens
  • Airway eosinophilia, cytokine production,
  • Airway hyperresponsiveness,
  • Airway smooth muscle thickening,
  • Goblet cell hyperplasia,
  • Subepithelial fibrosis,
  • Pulmonary vascular remodeling.

PASWe have previously shown efficacy of anticholinergics, in particular M3 selective anticholinergics, in this model using C57Bl/6 mice. Both C57Bl/6 and Balb/c mice can be used. Balb/c mice have more profound eosinophilic inflammation, whereas the remodeling is comparable between these strains.

Previous publications

–        Dragunas G, Woest ME, Nijboer S, Bos ST, van Asselt J, de Groot AP, Vohlídalová E, Vermeulen CJ, Ditz B, Vonk JM, Koppelman GH, van den Berge M, Ten Hacken NHT, Timens W, Munhoz CD, Prakash YS, Gosens R, Kistemaker LEM. Cholinergic Neuroplasticity in Asthma Driven by TrkB Signaling. FASEB J. 2020 Jun;34(6):7703-7717.

–        Kistemaker LEM, Bos IST, Hylkema MN, Hiemstra PS, Wess J, Meurs H, Kerstjens HAM & Gosens R. Muscarinic M3 Receptors Contribute to Allergen-induced Ariway Remodeling in Mice. Am J Respir Cell Mol Biol 2013.

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