Guinea pig models of COPD

Guinea pig model of acute LPS exposure

Features:

• Neutrophilic inflammation in the bronchoalveolar lavage fluid

We can test the effectiveness of your compound against this neutrophilic inflammation. We have previously demonstrated efficacy of anticholinergics and β₂ agonists in this model.

Previous publication

–        Smit M, Zuidhof AB, Bos IST, Maarsingh H, Gosens R, Zaagsma J, Meurs H. Effects Of Olodaterol And Tiotropium On Lipopolysaccharide-Induced Airway Hyperresponsiveness And Inflammation. Am J Respir Crit Care Med 2013;187:A1955.

Guinea pig model of chronic LPS exposure

Features:

• Twice weekly LPS challenges for 12 weeks,
• Tissue neutrophilia and cytokine production,
• Collagen deposition around the small airways,
• Mucus gland hypertrophy, goblet cell hyperplasia,
• Right ventricle remodeling.

We have previously shown efficacy of anticholinergics and GSK-3 inhibitors in this model.

Previous publications

–        Baarsma HA, Bos S, Meurs H, Visser KH, Smit M, Schols AM, Langen RC, Kerstjens HA, Gosens R. Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology. Respir Res. 2013;23;14:113.

–        Pera T, Zuidhof A, Valadas J, Smit M, Schoemaker RG, Gosens R, Maarsingh H, Zaagsma J, Meurs H. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD. Eur Respir J 2011; 38:789-96.