Guinea pig model of acute LPS exposure
Features:
- Neutrophilic inflammation in the bronchoalveolar lavage fluid
We can test the effectiveness of your compound against this neutrophilic inflammation. We have previously demonstrated efficacy of anticholinergics and β2 agonists in this model.
Previous publication
– Smit M, Zuidhof AB, Bos IST, Maarsingh H, Gosens R, Zaagsma J, Meurs H. Effects Of Olodaterol And Tiotropium On Lipopolysaccharide-Induced Airway Hyperresponsiveness And Inflammation. Am J Respir Crit Care Med 2013;187:A1955.
Guinea pig model of chronic LPS exposure
Features:
- Twice weekly LPS challenges for 12 weeks,
- Tissue neutrophilia and cytokine production,
- Collagen deposition around the small airways,
- Mucus gland hypertrophy, goblet cell hyperplasia,
- Right ventricle remodeling.
We have previously shown efficacy of anticholinergics and GSK-3 inhibitors in this model.