Mouse models of asthma
Features:
- Ovalbumin, house dust mite exposure or mixed allergens
- Airway eosinophilia, cytokine production,
- Airway hyperresponsiveness,
- Airway smooth muscle thickening,
- Goblet cell hyperplasia,
- Subepithelial fibrosis,
- Pulmonary vascular remodeling.
We have previously shown efficacy of anticholinergics, in particular M3 selective anticholinergics, in this model using C57Bl/6 mice. Both C57Bl/6 and Balb/c mice can be used. Balb/c mice have more profound eosinophilic inflammation, whereas the remodeling is comparable between these strains.