Mouse models of COPD

Mouse models of COPD

Mouse model of cigarette smoke-induced inflammation

Features:

• Infiltration of macrophages and neutrophils in the lung,
• Cytokine production and growth factor release.

We have previously shown efficacy of anticholinergics, in particular M₃ selective anticholinergics, in this model.

Previous publication

–        Kistemaker LEM, Bos IST, Hylkema MN, Nawijn MC, Hiemstra PS, Wess J, Meurs H, Kerstjens HAM, Gosens R. Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice. Eur Respir J 2013; 42:1677-88.