Mouse models of lung fibrosis


  • Single bleomyocin or silica exposure,
  • Lung function analysis by FlexiVent,
  • Inflammation (cell differentials, cytokine release),
  • Fibronectin and collagen expression,
  • Hydroxyproline analysis,
  • Masson-Goldner staining.


Previous publication

–        Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M. TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8. FASEB J. 2016;30(5):1823-35.


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