Precision cut lung slices provide a model system to study various aspects of airway and lung physiology and pathophysiology.
From human or animal tissue, the aspects that can be recapitulated include airway narrowing, emphysema and alveolar repair, airway remodeling and inflammation.
Advantages of ex vivo lung slices include:
-Natural architecture of the slices
-Preservation of cell-cell contacts and cell-matrix interactions
-Reduction of number of animals needed
-Direct comparison of experimental treatments with a control from the same animal or patient.
There are numerous possibilities for studies with ex vivo lung slices.
Feel free to Contact us with your specific questions. And see how we can implement your compound in one of our ex vivo lung slice models.