Entries by R. Gosens

Elastase-Induced Parenchymal Disruption and Airway Hyper Responsiveness in Mouse Precision Cut Lung Slices: Toward an Ex vivo COPD Model

Van Dijk EM, Culha S, Menzen MH, Bidan CM & Gosens R. Front Physiol. 2017 Jan 4;7:657. Publication: http://www.ncbi.nlm.nih.gov/pubmed/28101062 Abstract Background: COPD is a progressive lung disease characterized by emphysema and enhanced bronchoconstriction. Current treatments focused on bronchodilation can delay disease progression to some extent, but recovery or normalization of loss of lung function is impossible. Therefore, […]

Bronchoconstriction induces TGF-β release and airway remodeling in guinea pig lung slices.

Oenema TA, Maarsingh H, Smit M, Groothuis GH, Meurs H & Gosens R. Plos One, 2013, Jun 26;8(6):e65580. Publication: http://www.ncbi.nlm.nih.gov/pubmed/23840342 Abstract Airway remodelling, including smooth muscle remodelling, is a primary cause of airflow limitation in asthma. Recent evidence links bronchoconstriction to airway remodelling in asthma. The mechanisms involved are poorly understood. A possible player is the multifunctional cytokine TGF-β, […]

Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD.

Pera T, Zuidhof A, Valadas J, Smit M, Schoemaker RG, Gosens R, Maarsingh H, Zaagsma J, Meurs H. Eur Respir J., 2011, Oct;38(4):789-96. Publication: http://www.ncbi.nlm.nih.gov/pubmed/21349917 Abstract Airway remodelling and emphysema are major structural abnormalities in chronic obstructive pulmonary disease (COPD). In addition, pulmonary vascular remodelling may occur and contribute to pulmonary hypertension, a comorbidity of COPD. […]

Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison.

Bos IS, Gosens R, Zuidhof AB, Schaafsma D, Halayko AJ, Meurs H, Zaagsma J. Eur Respir J., 2007, Oct;30(4):653-61. Publication: http://www.ncbi.nlm.nih.gov/pubmed/17537779 Abstract Chronic inflammation in asthma and chronic obstructive pulmonary disease drives pathological structural remodelling of the airways. Using tiotropium bromide, acetylcholine was recently identified as playing a major regulatory role in airway smooth muscle remodelling […]

Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling.

Gosens R, Bos IS, Zaagsma J, Meurs H. Am J Respir Crit Care Med., 2005, May 15;171(10):1096-102. Publication: http://www.ncbi.nlm.nih.gov/pubmed/15695490 Abstract Rationale: Recent findings have demonstrated that muscarinic M(3) receptor stimulation enhances airway smooth muscle proliferation to peptide growth factors in vitro. Because both peptide growth factor expression and acetylcholine release are known to be augmented […]

Relationships among allergen-induced early and late phase airway obstructions, bronchial hyperreactivity, and inflammation in conscious, unrestrained guinea pigs.

Santing RE, Olymulder CG, Zaagsma J, Meurs H.  J Allergy Clin Immunol., 1994, 93:1021-1030.  Publication: http://www.ncbi.nlm.nih.gov/pubmed/8006307 Abstract The relationship among allergen-induced early asthmatic reactions (EARs) and late asthmatic reactions (LARs), early (between EAR and LAR) and late (after LAR) changes in bronchial reactivity to histamine and infiltration of inflammatory cells into the airways were investigated with a […]